glutathione reductase oxidative stress Mitochondrial in Cellular Redox Homeostasis and Disease Manifestation Frontiers | Lifestyle, Oxidative Stress,

Over time, the genome becomes increasingly dysregulated: DNA regions that should be silent become noisy, protective genes are switched off, and chromatin, the scaffold of DNA wrapped around histones (imagine them like packaging bundles), becomes condensed and brittle, losing its flexibility

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The high or moderate increase in ROS seems detrimental for myocardial cells, while its physiological level is necessary for normal cell signaling (123)

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Recent studies by Ogunjimi et al